Ying-Ying Jin

Abstract Ageing leads to diurnal misalignment with a global reduction in physiological fitness, yet the mechanisms underlying such age-related diurnal reprogramming and its role in ageing remain poorly understood. Here we generate diurnal transcriptomes across eight peripheral tissues and reveal that disrupted redox oscillations are common diurnal alterations in organismal ageing.

Background Livedoid vasculopathy (LV) is a rare, chronic, and recurrent cutaneous vascular obstructive disease, with clinical manifestations broadly classified into three stages. The first stage presents as purplish-red maculae and papules, often symmetrically distributed in the lower limbs, ankles, and back of the foot. The second stage progress into painful ulcers.

Abstract Despite the potential of small molecules and recombinant proteins to enhance the efficiency of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed and chemically modified, remain suboptimal for precise gene editing. Here, we screen the biased ssDNA binding sequences of DNA repair-related proteins and engineer RAD51-preferred sequences into HDR-boosting modules for ssDNA donors.