Ying Yuan
Houston
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Safety and Immunogenicity of SW-BIC-213, a Modified COVID-19 Lipo-Polyplex mRNA Vaccine, in Laotian Healthy Adults Aged 18 Years and Above: A Phase 1/2 Trial
You are already at the latest version We evaluated the safety and immunogenicity of SW-BIC-213, a Lipo-Polyplex (LPP)-based mRNA vaccine against SARS-CoV-2, administered as a two-dose regimen 21 days apart in healthy adults in Laos. In this phase 1/2 trial, healthy adults aged 18–60 years (phase 1) or ≥18 years (phase 2) were enrolled at Mahosot Hospital (Vientiane) and Champhone District Hospital (Savannakhet). In phase 1, 41 participants received either 25 μg or 45 μg of SW-BIC-213.
Financial market high-low volatility spillover and portfolio allocation: a time frequency analysis
ABSTRACT This study explores the high- and low-volatility spillover effects and portfolio allocation from a frequency-domain perspective across the stock, bond, forex, gold, and oil markets. Specifically, we decompose realized volatility into high- and low-volatility regimes and analyse volatility spillovers from both short- and long-term components using the TVP-VAR frequency connectedness approach.
Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion
Keywords lactate STING PKM2 LDHA EGFRvIII PD-1 immune evasion Get full text access Log in, subscribe or purchase for full access. References 1. Li, T. ∙ Chen, Z.J. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer J. Exp. Med. 2018; 215:1287-1299 2. Roers, A. ∙ Hiller, B. ∙ Hornung, V. Recognition of Endogenous Nucleic Acids by the Innate Immune System Immunity. 2016; 44:739-754 3. Sun, L. ∙ Wu, J. ∙ Du, F. ...
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