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Ying Zha on Muck Rack

Ying Zha

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Articles

NRIP1 co-activates nuclear translocated FOXO3 to upregulate TFAM expression and promote radioresistance in non-small cell lung cancer

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By Ying Zha, Hui Huang, Yulian Liu, Mengzhi Wan, Qinqin Yao, Hongtao Chen, Jianping Xiong, Min Zhong
| Nature Verified
Abstract Radioresistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). This study investigated the coordinated regulation of TFAM, FOXO3, and NRIP1 in NSCLC radioresistance. Radioresistant cell lines (A549-RR and H157-RR) were established to examine the effects of silencing these factors on cellular responses to radiation. In vivo, the impact of FOXO3 knockdown on tumor growth under irradiation was evaluated using A549-RR xenografts.
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