Ying Zhao
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A metabolite-pair controlled quiescence switch via ATP-dependent phase separation
Abstract Amino acid oxidation during carbon starvation inevitably generates NH₄⁺ and HCO₃⁻ as byproducts. Here we show that this metabolite pair acts synergistically to deplete cellular ATP, a task neither accomplishes alone. Rather than nutrient starvation itself, it is this specific energy crisis that triggers quiescence.
Higher frequencies of CNV deletions in bipolar disorder among Chinese Population
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Abstract Although copy number variants (CNVs) represent well-established genetic contributors to schizophrenia (SCZ), their role in bipolar disorder (BD), especially within non-European ancestries, has been inadequately explored. We evaluated the genome-wide load of rare CNVs, encompassing deletions and duplications, in a Han Chinese sample of 3915 BD cases and 7820 ethnically matched controls.
By Yong Wu, Xiangyu Li, YaoYao Sun, Yaoyao Sun, Chuyi Zhang, Ping Sun, Li Hui, Ying Zhao, Xiaoyang Feng, Baokun Wang, Jianzhong Yang, Nan Zhang Verified, Jing Yuan, Hongyan Jiang, Yuqi Cheng, Simeng Ma, Qian Gong, Yongfeng Yang, Wenqiang Li, Luxian Lv, Dongsheng Zhou, Xingxing Li, Xiaogang Chen, Chen Zhang, Xueqin Song, Wenxin Tang, Zhongchun Liu, Yongyong Shi, Xiao Xiao, Weihua Yue, Zhiqiang Li, Ming Li, Xuyuan Yin
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Nature
Verified
Dynamic Seed Topic Construction and LLM-Driven Multi-Topic Identification for Social Q&A Platforms
Social Q&A platforms produce short, noisy, and highly diverse user questions, making coarse topic labels insufficient for accurate information organization. This study proposes a dynamic seed topic construction and multi-demand topic identification framework for health science popularization questions on the Zhihu platform.
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