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Yingbo Gong on Muck Rack

Yingbo Gong

As seen in: Nature, Royal Society of Chemistry, EJSO - European Journal of Surgical Oncology
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Articles

LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC

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By Yingbo Gong, Atsushi Onodera, Naoko Hashimoto, Takahiro Fuchigami, Ryota Kurimoto, Hidemi Suzuki, Hongye Yu, Mingyang Chen, Masataka Yokoyama, Ikki Sakuma, Takashi Kono, Takashi Miki, Shinichiro Motohashi, Yusuke Kawashima, Osamu Ohara, Satoshi Yamashita, Tatsuya Suzuki, Shuichi Ohkubo, Tomoaki Tanaka, Takumitsu Machida, Sayaka Tsukioka, Akitoshi Nakayama, Motoi Nishimura, Tomohiro Ogino, Yasufumi Uematsu, Yuki Taki, Ryo Hatanaka, Yasuo Kodama
| Nature Verified
Abstract Small cell lung cancer (SCLC) is aggressive with limited treatment options, requiring new therapies. Lysine-specific histone demethylase 1 A (LSD1) maintains neuroendocrine state by repressing NOTCH/TGF-β signaling; their reactivation suppresses proliferation and induces differentiation. However, mechanisms of LSD1 inhibition and chemoresistance remain unclear.
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Clinical and pathological staging of gastric cancer: Current perspectives and implications

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By Zhi Zhu, Heping District, Yingbo Gong, Huimian Xu
| EJSO - European Journal of Surgical Oncology Verified
Abstract Accurate categorization of invasive depth and lymph node metastasis or optimization of TNM categories is fundamentally critical for prognostic assessment and decision making regarding subsequent therapies after surgery for gastric cancer. Improving the precision of the TNM staging is the ongoing goal. The evolution of the staging system indicates that there is no “ideal staging”. Every update has criticized the lack of a standard approach for the stages to date.
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A novel lymph node staging system for gastric cancer including modified Union for cancer Control/American Joint Committee on cancer and Japanese Gastric Cancer Association criteria

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By Yingbo Gong, Xin Wang, Siwei Pan, Guolian Zhu
| EJSO - European Journal of Surgical Oncology Verified
Abstract Background The TNM system of the International Union for Cancer Control/American Joint Committee on Cancer (UICC/AJCC) and the Japanese Gastric Cancer Association (JGCA) systems are the most used lymph node (LN) staging systems in gastric cancer. This study estimated the influence of anatomic location-based node stations on survival and proposed a new staging method based on both the number and anatomical distribution of metastatic LNs (mLNs).
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