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mNGS-Assisted Diagnosis of Visceral Leishmaniasis Presenting as Hemophagocytic Lymphohistiocytosis: Two Cases Confirmed by rK39
Introduction Visceral leishmaniasis (VL) is a severe parasitic disease caused by infection with Leishmania parasites, primarily transmitted through the bite of female sandflies, and is clinically known as kala-azar.1,2 The parasites predominantly reside in the mononuclear phagocyte system, proliferating extensively within macrophages in organs such as the liver, spleen, bone marrow, and lymph nodes, leading to systemic reticuloendothelial hyperplasia and functional impairment.2 Currently,...
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