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Yingchao Fang on Muck Rack

Yingchao Fang

As seen in: Nature, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles

Targeting phenol-soluble modulin α3-driven M1 macrophage polarization and necroptosis mitigates MRSA infection in mice

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By Bo Ma, Zhi Li, Hua Xu, Yuting Chen, Yingchao Fang, Jianwei Xie
| Nature Verified
Abstract The growing antibiotic resistance and high mortality rates associated with methicillin-resistant Staphylococcus aureus (MRSA) pose a global health threat, highlighting the urgent need for novel therapeutic strategies. Phenol-soluble modulin α3 (PSMα3) is a critical virulence factor in MRSA pathogenesis and immune evasion. However, its underlying mechanisms remain unclear. Here, we demonstrate that PSMα3 promotes both M1 macrophage polarization and necroptosis.
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