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Yingcheng Lyu on Muck Rack

Yingcheng Lyu

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Articles

Crizotinib inhibits activation of MET pathway caused by MET extracellular SEMA domain duplication

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By Gene Regulation, Sun Yat-sen, Jiatong Lin, Yingcheng Lyu
| Lung Cancer Verified
Highlights • A novel MET SEMA domain duplication was identified in a non-small cell lung cancer patient. • Off-label use of the kinase inhibitor crizotinib led to a marked response of the patient. • Cellular analyses provide a functional basis for the oncogenic role of the structural MET alteration. • The novel MET mutation may represent actionable targets in lung cancer patients.
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