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Health Economic Evaluations of Circulating Tumor DNA Testing for Cancer Screening: Systematic Review
1 Introduction Detection of cancer is a global healthcare challenge, and early detection is critical to provide timely cancer treatment [1-3]. In recent years, the application of circulating tumor DNA (ctDNA) as a biomarker for liquid biopsy has emerged for cancer screening [4-8]. ctDNA is a subset of cell-free DNA (cf-DNA) that originates from tumor cells [4, 5]. It carries tumor-specific genetic information and circulates in the bloodstream [9].
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