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Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA lin-4 during C. elegans development
eLife assessment The microRNA lin-4, originally discovered in C. elegans, has a key role in controlling developmental timing across species, but how its expression is developmentally regulated is poorly understood. Here, the authors provide convincing evidence that two MYRF transcription factors are essential positive regulators of lin-4 during early C. elegans larval development.
MYRF: A unique transmembrane transcription factor‐ from proteolytic self‐processing to its multifaceted roles in animal development
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES 1, & (2014). Myelination of the nervous system: Mechanisms and functions. Annual Review of Cell and Developmental Biology, 30, 503–533. 2, & (2016). The cell biology of CNS myelination. Current Opinion in Neurobiology, 39, 93–100. 3, , , & (2019). Myelin in the central nervous system: Structure, function, and pathology. Physiological Reviews, 99, 1381–1431. 4, , , & (2021).
Essential Function of Membrane-Bound Transcription Factor MYRF in Promoting Transcription of miRNA lin-4 during C. elegans Development
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