Yingchun Ling

Abstract Urolithins are gut microbiota-derived metabolites generated from ellagitannins and ellagic acid, and have emerged as promising mediators at the diet–microbiota–host interface. Interest in this metabolite family has increased substantially owing to growing evidence that urolithins, particularly urolithin A, influence mitochondrial quality control, autophagy, inflammatory signaling, and metabolic homeostasis across multiple tissues.