Yingcong Guo

This study revealed miR-182-5p as a key regulator of renal ischemia–reperfusion injury (IRI), whose upregulation promoted ferroptosis by inhibiting the SIRT1/Nrf2 pathway. In addition, the authors' team effectively alleviated IRI in preclinical models by developing LTH-anchored exosomes for targeted kidney delivery, achieving miR-182-5p inhibition. These findings highlight a novel therapeutic strategy and provide clinical potential for the treatment of IRI.

Corresponding Author Xuefang Wang College of Marine Sciences, Shanghai Ocean University, Shanghai, China National Distant-water Fisheries Engineering Research Center, Shanghai, China Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China Key Laboratory of Sustainable Utilization of Oceanic Fisheries, Ministry of Agriculture and Rural Affairs, Shanghai, China Correspondence Xuefang Wang, College of Marine...