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Yingcong Lin on Muck Rack

Yingcong Lin

As seen in: Wiley Online Library, Frontiers in Immunology
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Articles

Oxeiptosis-associated transcriptional states, immune heterogeneity, and oxidative-stress susceptibility in triple-negative breast cancer

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By Ziyun Zhuang, Haiyu Zhang, Jiawei Lei, Yingcong Lin, Ciqiu Yang, Yitian Chen, Changgui Zou
| Frontiers in Immunology
Abstract Background: Triple-negative breast cancer (TNBC) exhibits substantial variation in treatment response. In the phase 2 NeoSAC trial, higher baseline oxeiptosis-associated transcriptional activity was associated with pathological complete response (pCR). However, the malignant-cell and immune features underlying this transcriptional state remain poorly defined, as do the molecular factors that influence cellular susceptibility to oxidative stress.
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TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3‐mediated A1 differentiation of astrocytes

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By Jian Shen, Genghuan Wang, Liping Zhai, Yingcong Lin
| Wiley Online Library Verified
Abstract Aim We investigated the mechanism, whereby tumor necrosis factor-like ligand 1A (TL1A) mediates the A1 differentiation of astrocytes in postoperative cognitive dysfunction (POCD). Methods The cognitive and behavioral abilities of mice were assessed by Morris water maze and open field tests, while the levels of key A1 and A2 astrocyte factors were detected by RT-qPCR.
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