Yingdi ZHU

The selective and site-specific chemical labeling of proteins has emerged as a pivotal research area in chemical biology and cell biology. An effective protein labeling typically meets several criteria, including high specificity, rapid and robust conjugation under physiological conditions, operation at low concentrations with biocompatibility, and minimal perturbation of the protein function and activity.

Methodology Description As illustrated in Figure 1A, the methodology is composed of three steps, including (i) adhesive collection of cells from the surface of suspicious skin regions using sterile adhesive sampling discs (“sampling”), (ii) recording mass fingerprints of the collected skin cells on the sampling discs by MALDI-TOF mass spectrometry (“measurement”), and (iii) interpretation of the skin surface mass fingerprint data using similarity scoring algorithms, peak tracking method, and...

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