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STAT3-derived EIF4E3 promotes H 2 O 2 -induced human trabecular meshwork cell injury by activating TGF-β-SMAD2/3 pathway
Abstract The dysfunction of HTM cells involves key functions in the pathogenesis of glaucoma. In this study, we aimed to explore the functions of EIF4E3 and its regulatory mechanism in HTM cell injury, thereby illustrating the potential role of EIF4E3 in glaucoma. H2O2-treated HTM cells were adopted to mimic the glaucoma pathological condition in vitro. Functional experiments were performed using MTT, EdU, and flow cytometry assays, respectively.
Altered neurostructural development in magnetic resonance imaging‐negative pediatric epilepsy: A large‐scale multicenter study of 1919 children
This large-scale MRI study (n = 1919) reveals dynamic neurodevelopmental deviations in children with MRI-negative epilepsy. A critical 4–9-year vulnerability window features atypical cortical maturation, increased WMH burden, and delayed cortical morphology. Regarding epilepsy-associated sequential gray matter expansion, limbic dominance (5–6 years) precedes thalamic changes (9–12 years) with cerebellar volumetric shifts.
[2510.19186] Multi-Faceted Evaluation of Tool-Augmented Dialogue Systems
arXiv:2510.19186 (cs) View PDF HTML (experimental) Comments: Subjects: Computation and Language (cs.CL) Cite as: arXiv:2510.19186 [cs.CL] (or arXiv:2510.19186v1 [cs.CL] for this version) https://doi.org/10.48550/arXiv.2510.19186 Submission history From: Shamik Roy [ view email] [v1] Wed, 22 Oct 2025 02:44:11 UTC (16,583 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps Toggle Litmaps...
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