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Identification of prostate cancer bone metastasis related genes and potential therapy targets by bioinformatics and in vitro experiments
1 INTRODUCTION Prostate cancer (PCa) has emerged as the most prevalent malignancy in males and the second leading cause of cancer-related deaths among men.1 Although localized PCa is often curable, the number of patients initially diagnosed at a metastatic stage has increased significantly in the last decade.2 Metastasis, particularly in the bones, represents a major cause of mortality in patients with PCa,3 affecting approximately 70%–90% of those with advanced disease.
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