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Frontiers | Correction: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo
CORRECTION article Volume 16 - 2025 | https://doi.org/10.3389/fphar.2025.1657343 In the Funding statement, an incorrect number was provided for National Natural Science Foundation of China (#82174189 and #81873109). The correct number is National Natural Science Foundation of China (#82174186 and #81873109). The original article has been updated.
Identification of tRNA-derived RNAs in adipose tissue from overweight type 2 diabetes mellitus patients and their potential biological functions
1 Introduction Type 2 diabetes mellitus (T2DM) is a cause of human suffering, with its prevalence increasing annually, affecting over 400 million people worldwide. This condition can severely compromise patients’ quality of life, lead to significant premature deaths, and place a heavy economic burden on global health resources (1, 2). Overweight or obesity, another common metabolic disorder, is now a recognized risk factor for T2DM (2).
Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis
Abstract Background Gypenosides (Gyp) are the main ingredient of the Chinese medicine, Gynostemma pentaphyllum. They are widely used in Asia as a hepatoprotective agent. Here, we elucidated the mechanism of Gyp in non-alcoholic steatohepatitis (NASH) with a focus on farnesoid X receptor (FXR)-mediated bile acid and lipid metabolic pathways. Methods NASH was induced in mice by high-fat diet (HFD) feeding, while mice in the control group were given a normal diet.
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