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Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance
1 Introduction The pathological mechanism(s) of sepsis are complex, often culminating in high mortality rates, and currently, there are no clinically approved drugs that specifically target this disease.[1] Our previous work has shown that pretreatment or “training” of innate immunity with bacterial lipoprotein (BLP), a Toll-like receptor 2 (TLR2) agonist, confers robust protection against sepsis-associated lethality both in bacterial infection-induced sepsis and cecal ligation and puncture...
H-shaped acoustic micro-resonator-based quartz-enhanced photoacoustic spectroscopy
Abstract An H-shaped acoustic micro-resonator (AmR)-based quartz-enhanced photoacoustic spectroscopy (QEPAS) sensor is demonstrated for the first time. The H-shaped AmR has the advantages of easy optical alignment, high utilization of laser energy, and reduction in optical noise. The parameter of the H-shaped AmR is designed based on the standing wave enhancement characteristic.
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