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Clinical efficacy of tofacitinib in active ankylosing spondylitis and dynamic changes in gut microbiota: an exploratory descriptive four-case series with 16S rRNA sequencing analysis
Abstract Objective: To describe short-term clinical outcomes and safety of tofacitinib in four patients with active ankylosing spondylitis (AS) using real-world data, and to explore dynamic changes in gut microbiota before and after treatment. Methods: Four patients with active AS received oral tofacitinib 5 mg twice daily for 6 months.
Modular Synthesis of Fluoro‐ and Polyfluoroalkyl‐Substituted N‐Heterocycles via Photocatalytic Radical‐Polar Crossover [3 + 2 + 1] Cyclization
Supporting Information Filename Description cjoc202501019-sup-0001-supinfo.pdfPDF document, 12.5 MB Appendix S1:Supporting Information References 1(a) ; The Unique Fluorine Effects in Organic Reactions: Recent Facts and Insights into Fluoroalkylations. Chem. Soc. Rev. 2016, 45, 5441−5454; (b) ; ; ; Radical Brook Rearrangement: Past, Present, and Future. Chem. Soc. Rev. 2025, 54, 1870−1904; (c) Fluoroalkylacylsilanes as Novel Ambiphilic Donor-Acceptor Carbene Precursors. Acc. Chem. Res. 2025, 58, 1519−1533.
Oxygen Migration-Defluorination Strategy Enables the Aminocarbonylation of Enaminones with o-Aminobenzamides and CF2Br2 | Organic Letters
Organic Letters Cite this: Org. Lett. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
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