Yinghui Peng

Background The past decade has witnessed a paradigm shift in cancer treatment with the advent of T cell-targeted immunotherapies, particularly immune checkpoint blockade (ICB),1 2 adoptive cell transfer,3 4 and cancer vaccines.5 6 While immunotherapies targeting immune checkpoints have proven most effective in patients with high tumor mutational burden (TMB)7 and abundant CD8+ T-cell infiltration,8 the centrality of T cells in cancer immunosurveillance does not diminish the importance of...

Abstract Perturbed protein synthesis plays a crucial role in the pathogenesis of autism spectrum disorder (ASD), but the altered translational pattern and underlying mechanism remain poorly understood. Here, we identified an exaggeration of global protein synthesis in the cerebral cortex of offspring mice following prenatal exposure of valproic acid (VPA), a well-established ASD model.

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