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Aging-Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin-Related Protein 1-Associated Mitochondrial Vulnerability
1 Introduction Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder, particularly common in middle-aged and older populations, and is closely associated with an increased risk of cardiovascular disease (Benjafield et al. 2019; Iannella et al. 2025; Yeghiazarians et al. 2021). Chronic intermittent hypoxia (CIH) is one of the central pathophysiological features of OSA.
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