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Yingjia Ding on Muck Rack

Yingjia Ding

As seen in: ACS Publications
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Articles

Gut Bacterial β-Glucuronidase Blockade by 1,3,4-Thiadiazole-Containing Thioester Inhibitors Mitigates Irinotecan-Induced Gastrointestinal Toxicity Click to copy article link Article link copied!

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By Keren Xu, Zekai Cui, Yingjia Ding
| ACS Publications
Abstract Click to copy section linkSection link copied! Gut microbial β-glucuronidase has attracted attention as a potential therapeutic target for mitigating irinotecan (CPT-11)-induced late-onset diarrhea and intestinal injury. Here, we designed and synthesized 60 thioester derivatives bearing a 1,3,4-thiadiazole moiety and evaluated their biological activities. In vitro, 3–5B (IC50 = 0.39 μM) exhibited potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS).
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