Yingjia Li
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Case Report: Hereditary transthyretin amyloidosis in a Chinese family with the transthyretin variant p.Y89H
Abstract Background: Hereditary transthyretin amyloidosis (hATTR) is a rare, life-threatening multisystem disorder caused by pathogenic variants in the transthyretin (TTR) gene. Its clinical manifestations are highly heterogeneous, frequently resulting in diagnostic delay or misdiagnosis.hATTR caused by the TTR p.Y89H variant is extremely rare and is associated with a phenotype characterized by predominant ocular and leptomeningeal involvement.
A vision-language foundation model improves preoperative diagnosis of follicular thyroid neoplasms using ultrasound images
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Abstract Preoperative discrimination between follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) remains challenging, as imaging and cytological approaches often show limited efficacy. Even fine-needle aspiration (FNA) biopsy and intraoperative frozen sections frequently fail to provide conclusive results.
By Shufang Pei, Xin McRae Chen, Hui Shen, Yingjia Li, Kai Yang, Juanjuan Liu, Bin Huang, Xuewei Wu, Ting Liang, Dan Yang, Yunjun Yang, Fei Wang, Jingjing You, Zhe Jin, Jie Sun, Lijuan Liu, Fei Guo, Zhihong Lan, Lizhu Ouyang, Shuyi Liu, Xiaoxiao Feng, Yue Huang, Shuixing Zhang, Zhong Liu, Bin Zhang, Wenle He, Guifeng Tu
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Nature
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Bioengineered photosynthetic nanothylakoids reshape the inflammatory microenvironment for rheumatoid arthritis therapy - Nature Nanotechnology Original
Abstract Reducing individual inflammatory factors does not always translate into clinical efficacy in rheumatoid arthritis (RA), an autoimmune disease characterized by joint inflammation. Proinflammatory M1 macrophages are a key driver of the hyperinflammatory joint microenvironment, which also promotes the progression of RA.
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