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Yingjia Yao

As seen in: Wiley Online Library, BioRxiv
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Articles

The Evolving Enantioselective C─H Functionalization of Tertiary Allylic Systems

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By Yuqing Chen, Yingjia Yao
| Wiley Online Library Verified
The direct functionalization of tertiary and other inert allylic C─H bonds represents one of the most attractive strategies in the construction of complicated molecules with quaternary carbon centers. Unlike approaches that rely on pre-functionalized allylic substrates, such as halides, acetates, and carbonates, allylic C─H activation provides an atom- and step-economical route to forge diverse and valuable C─C and C─X bonds.
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CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

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By Wen-Jie Jiang, Yingjia Yao, Zexu Li, Chunge Zhong
| BioRxiv
Abstract Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens for seven chemotherapeutic agents in multiple cancer cells.
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A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

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By Yunhan Zhang, Zexu Li, Zhisong Chen, Yingjia Yao
| BioRxiv
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