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Yingjian Lv

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Articles

TOPORS Deficiency Impairs TET2 SUMOylation leading to aberrant m5C Hypermethylation that promotes adipogenic differentiation of mesenchymal stem cells in osteoporosis

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By Yibin Zhang, Yunhui Zhang, Zihao Yuan, Quanfeng Li, Pengfei Ji, Ziyue Ma, Jianan Jiang, Mingxi Cai, Pei Feng, Peng Wang, Wenjie Liu, Guangqi Tian, Yingjian Lv
| Nature Verified
Abstract Osteoporosis is characterized by reduced bone mass and increased bone marrow adiposity, largely resulting from an imbalance between the osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs). Although posttranslational protein modification and RNA epitranscriptomic regulation are increasingly recognized as key determinants of MSC fate, their mechanistic involvement in osteoporosis remains unclear.
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