Yingjie Chen
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Early-pregnancy BMI-derived adiposity change rate and gestational diabetes mellitus risk: modification by a fatty liver index–defined hepatic-metabolic phenotype
Abstract Gestational diabetes mellitus (GDM) is commonly diagnosed at 24–28 weeks of gestation; however, metabolic susceptibility that precedes dysglycemia may emerge earlier. We examined whether the rate of early pregnancy body mass index (BMI)-derived estimated body fat percentage (eBFP) change was associated with subsequent GDM, and whether this association differed according to an early hepatic–metabolic phenotype defined by the natural log-transformed fatty liver index (FLI_Ln).
First-trimester SPISE mediates the association between early-pregnancy body fat percentage change and gestational diabetes mellitus: an exploratory secondary analysis of a prospective cohort
Abstract Background: Gestational diabetes mellitus (GDM) is closely related to maternal adiposity and insulin resistance. The rate of body fat percentage (BFP) change in early pregnancy may describe estimated BFP gain before routine glucose screening. The Single-Point Insulin Sensitivity Estimator (SPISE) offers a fasting estimate of insulin sensitivity without insulin testing. It is still uncertain whether SPISE explains the link between early BFP change and later GDM.
Association of atherogenic index of plasma and its modified indices with gestational diabetes mellitus: a prospective cohort study based on the Korean population
Abstract Background: Gestational diabetes mellitus (GDM) is a common pregnancy complication, yet current diagnosis at 24–28 weeks may occur after metabolic changes have already begun. The atherogenic index of plasma (AIP, log₁₀[TG/HDL-C]) has shown promise for early GDM risk stratification, but it does not incorporate obesity-related parameters.
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