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RNA-Seq Reveals the mRNAs, miRNAs, and lncRNAs Expression Profile of Knee Joint Synovial Tissue in Osteoarthritis Patients
4. Discussion OA affects the joints of the knees, hands, hips, and spine and is the main cause of limited mobility among the elderly [24,25]. Although genetic susceptibility, aging, obesity, and joint malalignment are risk factors for OA, the pathogenesis of OA is unclear [26,27]. Therefore, other than total joint replacement, interventions that delay disease progression and cartilage degeneration are currently unavailable [28].
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