Yingjie Qiu

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. Supporting Information Filename Description sim70743-sup-0001-Supinfo.pdfPDF document, 368.1 KB Section S1: Brief revisit of BOIN and gBOIN optimal boundary calculation. Section S2: Detailed Stage I dose combination exploration algorithm. Section S3: Additional simulation studies.

Abstract Click to copy section linkSection link copied! Effective management of infected wounds requires biomaterials that simultaneously combat infection, oxidative stress, and impaired healing. This study developed a green-synthesized multifunctional hydrogel (TP-Ag@BDH) by incorporating tea polyphenol (TP) and TP-capped silver nanoparticles (TP-AgNPs) into a BDDE-cross-linked matrix of deacetylated sphingan WL gum (DWL).