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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Interpretable deep learning framework for mapping E3–substrate binding interfaces
Abstract E3 ubiquitin ligases recognize substrates through specific interfaces. Accurate delineation of these interfaces is essential, as mutations disrupting them impair protein ubiquitination and drive cancer progression. However, available E3–substrate interface data are sparse and systematic prediction methods remain lacking.
A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions - Nature Communications
Abstract Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination. In comparison to the E3-substrate interactions, the DUB-substrate interactions (DSIs) remain insufficiently investigated.
An Efficient and High-Quality Mesh Reconstruction Method with Adaptive Visibility and Dynamic Refinement
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