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Yingjun Shi on Muck Rack

Yingjun Shi

As seen in: AIChE Journal, Nature
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Articles

Glutamine sequestration promotes tumor growth and immune evasion through elevation of arginine methylation in hepatocellular carcinoma

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By Jingjing Nian, Ziran Wang, Shiyi Chen, Yang Zhou, Xinyu Wang, Yingjun Shi, Yang Wang, Jiehui Li, Zhihan Li, Feiyang Fu, Yingchao Wang, Tobias Madl, Xiaolong Liu, Xiangrong Chen, Fangrong Zhang, Xiawei Fu, Yijiacheng Li, Xiaohuang Lin
| Nature Verified
Abstract Mechanisms underlying the immunosuppressive microenvironment in hepatocellular carcinoma (HCC) extend beyond immune checkpoints to include metabolic competition. Here, we identify a metabolic evasion pathway driven by SLC1A5 overexpression, which enables HCC cells to sequester glutamine from the tumor microenvironment (TME).
Open in Who Shared Issue with article?

Reduced glutathione enhances adipose tissue‐derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway

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By Yingchao Wang, Shaoxiong Yu, Yingjun Shi, Saihua Yu
| AIChE Journal Verified
Our study demonstrates that reduced glutathione (GSH) significantly enhances the engraftment efficiency of adipose-derived stem cell (ADSC) in liver fibrosis by targeting the TGFβ1/SMAD3/NOX4 signaling pathway. This finding highlights GSH's potential to improve ADSC-based therapies for liver diseases, providing a novel approach to reduce oxidative stress and promote cell engraftment.
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