Yingke Xu

Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells remain largely elusive.

Abstract The inhibition of estrogen receptor (ER)-mediated genomic signaling in ER-positive cancer cells has long been a primary focus of therapeutic strategies. Here, we introduce a switchable competitive inhibition system for ERα-mediated transcriptional regulation, termed DOCTER (Drug-induced On-Off Competitor for Transcription mediated by ERα). DOCTER integrates the Tet-On induced Cre-loxP recombination system to enable precise, reversible on/off switching.

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References 1, “Virus Morphology: Insights From Super-Resolution Fluorescence Microscopy,” Biochimica et Biophysica Acta, Molecular Basis of Disease 1868, no. 4 (2022): 166347, https://doi.org/10.1016/j.bbadis.2022.166347.