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Yinglan Ji

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Articles

The secretory protein, CLCF1, improves cholestatic liver disease by inhibiting hepatic bile acid synthesis and promoting bile acid excretion

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By Man Liu, Yujie Hu, Meng Shen, Yanqing Gong, Lingfei Wang, Yujie Zhang, Xiaoyi Wang, Hui Yang, Yongsheng Chang, Lu Zhou, Yingxi Su, Suriguge Bao, Yinglan Ji
| Nature Verified
Abstract Cholestatic liver disease (CLD) is characterized by disrupted bile acid (BA) homeostasis and excessive accumulation of toxic bile acids in the liver. While both genetic and acquired factors are known to contribute to its pathogenesis, the full spectrum of underlying pathological mechanisms remains incompletely understood, and treatment options are limited.
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