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Thieme E-Journals - Synlett
Buy Article Permissions and Reprints All articles of this category Bis(indolyl)methanes have attracted considerable attention for their interesting biological activities. Green organic-catalytic synthesis has promoted the development of green chemistry, especially in aqueous-phase reaction systems.
PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and Alleviates Chondrocyte Osteoarthritis Mediated by Exosomal ANXA1
Abstract Osteoarthritis (OA) is characterized by synovitis, cartilage degeneration and exercise therapy has been recognized as first line therapy. The exercise related exosome involved in the interaction between fibroblast-like synoviocytes (FLSs) and chondrocytes could be a novel promising strategy for treating OA. In this study, PPARγ was upregulated in FLSs under exercise by single cell transcriptome sequencing.
Co-interventions with Clostridium butyrate and soluble dietary fiber targeting gut microbiota improve MAFLD via the Acly/Nrf2/NFκ B signaling pathway
Co-interventions with Clostridium butyrate and soluble dietary fiber targeting gut microbiota improve MAFLD via the Acly/Nrf2/NFκ B signaling pathway Purpose: The pathogenesis of metabolic associated fatty liver disease (MAFLD) is complex. The lipid metabolic disorder, chronic inflammation, and oxidative stress are the core events for MAFLD. Dietary intervention is an important treatment strategy for preventing the onset and progression of MAFLD.
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