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Impact of dexmedetomidine administration timing on postoperative delirium in elderly patients with lower limb fractures: a study protocol for a randomised controlled trial
Discussion This randomised, placebo-controlled, prospective study was designed to evaluate the prophylactic capacity of dexmedetomidine administered at different timings (preoperative vs intraoperative) on POD among older individuals with lower limb fractures, with the goal of establishing the optimal intervention window. POD is a common and serious complication in elderly patients, with a complex pathogenesis.
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