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Trifluoromethyl Thianthrenium Salts: From Organic Synthesis to Materials
Over the past decades, the use of light in organic synthesis has grown exponentially thanks to the renaissance of photoredox catalysis, (25) energy transfer (26) and EDA complexes. (27) Compared with thermal methods, photochemical strategies often provide milder conditions, improved selectivity, and unique access to open-shell intermediates.
Trifluoromethyl Thianthrenium Salts: From Organic Synthesis to Materials
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2026, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.
Photochemical Construction of Trifluoromethyl Bicyclo[1.1.1]pentyl-heterocycles Original
Within medicinal chemistry settings, the 100% C(sp3)-hybridized and rigid bicyclo[1.1.1]pentane (BCP) scaffold has gained recognition as a competent bioisostere for monosubstituted phenyl and 1,4-disubstituted phenyl motifs in numerous cases, attracting increasing attention. (1) Particularly, 1,3-disubstituted BCPs can mimic the spatial orientation of para-substituted phenyl rings, albeit with a slightly shortened distance between the two substituents (Scheme 1A).
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