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CD39 + CD103 + CD8 + T cells enhance neoadjuvant chemoimmunotherapy efficacy in head and neck squamous cell carcinoma
Abstract Neoadjuvant chemoimmunotherapy (NACI) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. However, some patients still do not respond significantly, partly attributed to insufficient anti-tumor specific T-cells. Thus, identifying the underlying causes of impaired antitumor immunity has become an urgent priority to improve efficacy.
Effects of genetic variation on the structure of RNA and protein
• , , & ( ). A novel mutation in the promotor region in a family with a mild form of retinoblastoma indicates the location of a new regulatory domain for the RB1 gene . Oncogene, ( ), – . • , , , , , , & ( ). Moderate reduction of beta-globin gene transcript by a novel mutation in the 5' untranslated region: A study of its interaction with other genotypes in two families . Blood, ( ), – . • , , , , , , , & ( ).
A novel polyetherimide hydrogel proton exchange membrane
A novel polyetherimide hydrogel proton exchange membrane Here, we reported a novel rapidly-formed hydrogel membrane which crosslinked by polyetherimide and polyethyleneimine within 10s. The polyetherimide as backbone provided rigidity of the hydrogel membrane, the polyethyleneimine as crosslinker provided the hydrophilicity. The mechanical strength and electrical performance of the hydrogel membranes can be finely regulated by adjusting the ratio of the two polymers.
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