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Yingnan Yu on Muck Rack

Yingnan Yu

As seen in: Frontiers in Immunology
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Articles

Frontiers | Multi-omics profiling of sodium-overload (NECSO) programs identifies NEK8 as a central driver of colorectal cancer progression through single-cell and spatial transcriptomics

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By Yanchao Ji, Bo Yu, Xuedong Yin, Tianqi Yu, Xu Wu, Zheng Wang, Jiajun Zhao, Zhihao Fang, Yaxuan Wang, Zongrui Zhao, Xiangjie Gao, Yingnan Yu
| Frontiers in Immunology
1 Introduction Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide and a leading cause of cancer mortality (1). Although contemporary treatments—chemotherapy, surgical resection, targeted therapy, and immunotherapy—have improved survival, outcomes remain suboptimal because of marked intratumoral heterogeneity, therapeutic resistance, and the high recurrence of metastatic disease (2, 3).
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