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Brain radiotherapy added to first-line immunochemotherapy improves survival in patients with treatment-naïve, driver-negative lung adenocarcinoma and synchronous brain metastases
Abstract Objective: The optimal integration of brain radiotherapy with first-line immunochemotherapy for treatment-naïve, driver-negative lung adenocarcinoma patients with synchronous brain metastases remains unclear. This study assessed the efficacy and safety of this combined strategy.
Frontiers | Early brain radiotherapy combined with third-generation EGFR-TKIs improves survival in EGFR-mutant NSCLC with synchronous brain metastases: a multi-center retrospective analysis
1 Introduction Lung cancer remains the leading cause of cancer-related mortality globally, with non-small cell lung cancer (NSCLC) representing the predominant histological subtype (1). Brain metastases (BM) develop in approximately 44% of patients with advanced NSCLC, conferring a dismal prognosis and significantly impairing quality of life (2).
Preparation of a β-CD@Fe3O4/KHA/CMC/AM/MAH hydrogel and its slow-release herbicidal properties against glyphosate
Preparation of a β-CD@Fe3O4/KHA/CMC/AM/MAH hydrogel and its slow-release herbicidal properties against glyphosate This study employed β-cyclodextrin (β-CD) for the hydrophilic modification of iron tetraoxide (Fe3O4) magnetic materials. Subsequently, potassium humate (KHA) and carboxymethyl cellulose (CMC) were used as raw materials. A β-CD@Fe3O4/KHA/CMC/AM/MAH hydrogel with magnetic properties which can be easily recycled was synthesized for the slow release of glyphosate (GLY).
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