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Yingnv Gao

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Phycocyanin Prevents Methylglyoxal-induced Mitochondrial-Dependent Apoptosis in INS-1 cells by Nrf2

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By Chen Liu, Yingnv Gao, Guoqing Wan
| Chemistry World Verified
Methylglyoxal (MG) is a reactive dicarbonyl compound, which abnormal accumulation in diabetic patients exerts deleterious effects on cells and tissues. β-cell is the main target cell of Type 2 diabetes, and its insulin secretion injury and cell apoptosis can be due to mitochondrial dysfunction. Previous studies have demonstrated that MG induced β-cell apoptosis. However, little is known about the effect of MG on β-cell mitochondrial dysfunction.
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