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Articles

Combine immune checkpoint indoleamine 2,3-dioxygenase 1 knockdown with ferroptosis inducer Erastin/RSL3 accelerates colorectal cancer cell ferroptosis

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By Jiajia Xu, Taixi Xu, Yingpei Ling
| cytojournal.com
Colorectal cancer (CRC) remains a major challenge to global health. Recent data indicate that CRC is the third most prevalent cancer diagnosis globally and the second highest contributor to cancer mortality (American Cancer Society, 2022).[1] The rising global incidence of CRC underscores its growing threat to public health. Consequently, the development of innovative and effective therapeutic approaches remains a critical and pressing need.
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