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Yingqing Xie on Muck Rack

Yingqing Xie

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Articles

The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway

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By YUE LI, Wei Zhang, Dongyun Wang, Mengyu Liu, Weixia Han, Xinran Li, Shan Song, Lin Mu, Guiying Li, Yonghong Shi, Yingqing Xie
| Nature Verified
Abstract Itch, an E3 ubiquitin ligase, is involved in various cellular functions by regulating ubiquitination and proteasomal degradation of target proteins. However, its roles are unknown in kidney fibrosis. In the present study, the decreased expression of Itch in the renal tubules of patients with chronic kidney disease (CKD) and mice induced by unilateral ureteral obstruction (UUO) or folic acid (FA) is demonstrated.
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