Skip To Main Content
Yingquan Qin on Muck Rack

Yingquan Qin

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Yingquan

Contact Yingquan, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

CARD11 signaling regulates CD8+ T cell tumoricidal function - Nature Immunology

|
By YU HU, Qifan Zhao, Song Mei, Hecheng Li, Peng Zhang, Yan Zhang, Michael J. Lenardo, Yingquan Qin
| Nature Verified
Abstract Chronic stimulation in the tumor microenvironment can induce exhausted CD8+ T (Tex) cells that have limited tumoricidal activity. Here, we show an inverse correlation between signal strength and Tex cell differentiation by using patient-derived mutations in the T cell receptor (TCR)-signaling protein CARD11. Strong TCR signaling of the E134G mutant inhibits Tex cell differentiation and increases tumor growth.
Open in Who Shared Issue with article?
See all 1 articles