Yingsen Tang

1 Introduction Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are two major autoimmunity diseases with multi-organ involvement that appear to have an alternate relapsing and remitting course and are associated with high rates of disability and mortality in patients.[1] The hyperactivation of autoreactive B cells and plasma cells plays a crucial role in the pathogenesis of SLE and RA,[2] therefore, there is an urgent need to profoundly reset the abnormal humoral immune system...

ROS-responsive poly(β-amino ester) nanoparticle enables targeted delivery of mRNA vaccine to splenic antigen-presenting cells Intravenous mRNA vaccines show promise for stimulating immune cells but face challenges in targeting APCs due to high liver accumulation. To address this, we developed ROS-responsive PBAE nanoparticles, 93-TKA10-19, designed to target splenic APCs, enhance mRNA expression, and induce a Th1-skewed immune response, advancing mRNA vaccine efficacy.

Enhancing Spleen-Targeted mRNA Delivery with Branched Biodegradable Tails in Lipid Nanoparticles The application of mRNA therapy is constrained by the current lipid nanoparticles' (LNPs) inability to target non-liver tissues. In this study, we demonstrate that ionizable lipids equipped with branched, biodegradable tails enhance the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells.