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Yingshan N. Wei on Muck Rack

Yingshan N. Wei

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Articles

Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous irg1/acod1 tracking - Nature Communications

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By Caroline Spencer, Matthew Hamilton, Alison Rojas, Yingshan N. Wei
| Nature Verified
Abstract Macrophages are central drivers of chronic inflammation, yet how a sustained inflammatory state alters their function remains unclear. Using GFP knock-in zebrafish targeting irg1/acod1 that marks macrophage activation, we track the dynamic transitions of macrophage states during acute muscle injury under homeostatic and chronically inflamed conditions, induced by genetic mutation of nlrc3l.
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