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PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability
1C one-carbon 3-PG 3-phosphoglycerate GSH Reduced glutathione GSSG Oxidized glutathione disulfide IHC Immunohistochemistry NADP Nicotinamide adenine dinucleotide phosphate NADPH Nicotinamide adenine dinucleotide phosphate hydrogen NSCLC Non-small cell lung cancer PHGDH 3-phosphoglycerate dehydrogenase PSAT1 Phosphoserine aminotransferase 1 PSPH phosphoserine phosphatase ROS Reactive oxygen species SSP de novo serine synthesis pathway 1 Introduction Lung cancer, the leading cause of...
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