Yingsong Lin

Conflicts of Interest Masato Ozaka has received honoraria from MSD, AstraZeneca, Taiho, Ono, Novartis, and Servier Japan outside the present study. The other authors declare no conflicts of interest. Data Availability Statement The data supporting the conclusions of this study are included in this article and its files. Raw NPX values generated from the Olink Explore HT platform and further information are available from the corresponding author upon reasonable request.

8-OHdG 8-hydroxy-2-deoxyguanosine BMI body mass index CI confidence interval HR hazard ratio MR Mendelian randomization PY pack year 1 INTRODUCTION Obesity, as defined by BMI, is known to increase the risk of a wide range of diseases, including type 2 diabetes, cardiovascular disease, and cancer.1 Over the past several decades, there has been growing interest in exploring the associations of BMI with cancer incidence and mortality.

Genome-wide association studies (GWASs) have identified many single nucleotide polymorphisms (SNPs) that are significantly associated with pancreatic cancer susceptibility. We sought to replicate the associations of 61 GWAS-identified SNPs at 42 loci with pancreatic cancer in Japanese and to develop a risk model for the identification of individuals at high risk for pancreatic cancer development in the general Japanese population.