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Optimization of amino acid composition in CHO cell perfusion medium using definitive screening design and 1H NMR‐based consumption profiling
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , , et al. Mammalian cell culture for production of recombinant proteins: a review of the critical steps in their biomanufacturing. Biotechnol Adv. 2020; 43:107552. doi:10.1016/j.biotechadv.2020.107552 2, , , . Metabolic profiling of CHO cells during the production of biotherapeutics. Cells. 2022; 11(12):1929. doi:10.3390/cells11121929 3, , , et al.
Exploring metabolic responses and pathway changes in CHO‐K1 cells under varied aeration conditions and copper supplementations using 1H NMR‐based metabolomics
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description biot202300495-sup-0001-SuppMat.pdf568.4 KB Supporting Information REFERENCES 1 (2014). The history of monoclonal antibody development—progress, remaining challenges and future innovations. Annals of Medicine and Surgery, 3, 113–116. https://doi.org/10.1016/j.amsu.2014.09.001 2, , , , , , , & (2022). Hierarchical time-series analysis of dynamic bioprocess systems.
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