Yingting Zhu
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Two-year outcomes of trabeculo-canalectomy for glaucoma secondary to iridocorneal endothelial syndrome: a retrospective study
Abstract Background: The study aimed to evaluate the 2-year outcomes of a new surgical procedure for treating Chinese patients with glaucoma secondary to iridocorneal endothelial syndrome (GS-ICE). Methods: This was a retrospective study involving 26 GS-ICE patients (26 eyes) surgically treated with trabeculo-canalectomy in the First Affiliated Hospital with Nanjing Medical University from January 2015 to June 2024, and postoperatively followed up for 2 years.
NAD+ modulates mitochondrial vulnerability in MERTK-associated models of retinitis pigmentosa
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Abstract Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease leading to blindness. RP is characterized by progressive loss of photoreceptors and retinal pigment epithelium (RPE), leading to retinal degeneration. The mechanisms that initiate RP and drive retinal vulnerability are poorly understood, and new strategies for preventing and treating RP are urgently needed.
By Lujia Feng, Ting Zhang, Xiaohua Zhuo, Yantao Wei, Lixian Liu, Zhaohao Huang, Guoming Zhang, LU CHEN, Yong Du, Dong Fang, Wangting Li, Linbin Zhou, Ling Zhao, Yingting Zhu, Jia Liang, Zhiquan Li, Xiaojing Song, Xingxing Mao, Xiaofeng Hou, Wenru Su, Wei Chi, Yehong Zhuo, Shaochong Zhang, Yuwen Wen, Caibin Deng
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Nature
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Metal ions in aging and ocular diseases: biology, pathophysiology, and therapeutic strategies
Abstract Metal ions are indispensable for sustaining normal cellular functions and preserving tissue integrity, as they participate in enzymatic catalysis, signal transduction, and antioxidant defense. However, dysregulation of metal ion homeostasis, particularly during aging, disrupts cellular balance and significantly drives the development and progression of age-related ocular diseases, including age-related macular degeneration, glaucoma, diabetic retinopathy, and cataracts.
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