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Yinguang Liao on Muck Rack

Yinguang Liao

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Articles

Fluid shear stress inhibits vascular endothelial cells proliferation via EGR1/Grem1 axis

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By Jiajun Qian, Yong Wu, Xiaoyan Li, Zhiqiang Zha, Fangjian He, Yinguang Liao
| Nature Verified
Abstract Pulmonary hypertension (PH) is associated with fluid shear stress (FSS) and Gremlin1 (Grem1), but the mechanism by which FSS acts on Grem1 remains unclear. Here we found that FSS downregulated Grem1 in bEnd.3 cells. Meanwhile, FSS inhibited the expression of transcription factor EGR1. Mechanistically, FSS inhibited the transcriptional activity of Grem1 promoter by down-regulating EGR1.
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