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Multilevel synergistic anticancer mechanisms of Punica granatum L. peel polyphenols targeting the pan-cancer proliferation target PCNA: a combined analysis based on network pharmacology, molecular dynamics simulation, and UPLC-Q-TOF-HRMS
Abstract Punica granatum L. peel is rich in tannins and flavonoids. Modern pharmacological studies have indicated its multi-target anticancer potential; however, the molecular recognition mechanisms between its active components and key targets remain to be systematically clarified.
Zanubrutinib-rituximab followed by shortened chemoimmunotherapy as frontline treatment for mantle cell lymphoma (CHESS): a phase II trial
Abstract A combination of Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib and rituximab has shown promising efficacy in mantle cell lymphoma (MCL). This phase II trial evaluated the second-generation BTK inhibitor zanubrutinib plus rituximab as induction, followed by shortened chemoimmunotherapy as frontline treatment for MCL (NCT04624958). Eligible patients had histologically confirmed stage II–IV disease requiring immediate therapy and no prior MCL-related systemic treatment.
Artificial Intelligence in CT for Predicting Cervical Lymph Node Metastasis in Papillary Thyroid Cancer Patients: A Meta-analysis
Abbreviations LNM (lymph node metastasis) PTC (papillary thyroid cancer) DECT (dual-energy CT) TP (true positive) TN (true negative) FP (false positive) FN (false negative) ROC (receiver operating characteristic) CI (confidence intervals) SROC (summary receiver operating characteristic) AI (artificial intelligence) AUC (area under the curve) Key Words Artificial intelligence Computed tomography Papillary thyroid cancer Lymph node metastasis Meta-analysis Get full text access Log in, subscribe...
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